منابع مشابه
Uridine Prevents Fenofibrate-Induced Fatty Liver
Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are examined. At a daily dosage of 400 mg/kg, fenofibrate treatment causes reduction of liver NAD(+)/NADH ratio, induces hyper-acetylation of peroxi...
متن کاملLamivudine-Induced Liver Injury
BACKGROUND Lamivudine is a nucleoside analogue antiretroviral drug, known for its low toxicity at clinically prescribed dose. However, the toxicity or mechanism of toxicity and target tissue effects during prolonged administration of higher doses were hardly given sufficient laboratory attention. AIM The present work was designed to investigate the biochemical and histopathological changes in...
متن کاملNitrofurantoin Induced Liver Injury
Drug induced liver injury is a recognised cause of acute liver failure. A wide range of drugs have been implicated, of which the most common are Paracetamol and antibiotics. Nitrofurantoin is a commonly prescribed antimicrobial which may cause liver injury from either acute or chronic exposure. This complication was thought to occur with an extremely low incidence; however recent data suggests ...
متن کاملDrug-Induced Liver Injury
1Office of Computational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA 2Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany 3Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA 4Division of Bioinformatics and Biostatistics, National Center for Toxicological Research,...
متن کاملThiocolchicoside-induced liver injury
Drug-induced liver injury (DILI) is an important cause of mortality and morbidity in the general population. Patients suffering from DILI may present with symptoms ranging from minor, nonspecific changes in hepatic structure and function to fulminant hepatic failure or chronic hepatitis. Thiocolchicoside is widely used as a muscle relaxant. The primary side effects of thiocolchicoside are nause...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2005
ISSN: 1007-9327
DOI: 10.3748/wjg.v11.i48.7702